Over-the-counter (OTC) medications play an invaluable role in the healthcare system by providing accessible, affordable treatment options to millions of Americans every day. Unlike prescription drugs, OTC medicines can be purchased without a prescription and come in user-friendly forms that enable consumers to better manage minor, short-term conditions. The safety and effectiveness of active ingredients in approved OTC products have undergone thorough FDA review, so consumers can feel confident in using them as directed. Ingredients must demonstrate real benefits that outweigh potential risks before being marketed directly to the public in specified dosages. Thanks to their oversight by the FDA, wide availability at pharmacies and retail stores, and lower costs, OTC pain relievers, antihistamines, cough suppressants, and other medications continue to offer consumers effective, reasonably safe treatment alternatives for all ages — saving many a trip to the doctor’s office. Their convenience and budget-friendliness make them a staple of at-home healthcare regimens for both adults and children.